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KMID : 1123920110250050837
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Korean Journal of Oriental Physiology and Pathology
2011 Volume.25 No. 5 p.837 ~ p.842
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Effect of Lespedeza Cuneata G. Don on the Activity of Murine Immune Cells
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Eun Jae-Soon
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Abstract
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The purpose of this research was to investigate the effects of 50% ethylalcohol extracts of Lespedeza cuneata G. Don (LE) on the activity of murine immune cells. LE was administered orally once a day for 7 days at the dose of 250 mg/kg. LE increased the cell viability of thymocytes, splenocytes and peritoneal macrophages in vitro and in vivo system, but decreased the cell viability of thymocytes and splenocytes in the presence of concanavalin A in vivo system. Also, the administration of LE was increased the production of ?-interferone, but did not affect the production of interleukin-2 and interleukin-4. Furthermore, LE decreased the phagocytic activity of peritoneal macrophages in vitro and in vivo system, but enhanced the production of nitric oxide. These results suggest that LE has a immuno-regulative action via stimulation of immune cells proliferation.
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KEYWORD
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Lespedeza cuneata G. Don, thymocytes, splenocytes, macrophages
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